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Scaffolds and cross-talk in Saccharomyces cerevisiae MAPKinase signaling

Canonical three tier MAPKinase cascades are central to many eukaryotic signaling networks, and essential for cellular adaptation to changing environments. Evolutionary conservation of core components and signaling mechanisms have made the budding yeast S. cerevisiae the ideal model organism to study individual MAPKinase pathways and the interactions between cascades involved in adaptation to different environmental challenges. I intend to discuss some of our previous and ongoing work on the MEKK Ste11p, a shared component between three different pathways, which has provided some insight in pathway insulation. Our experiments with Ste11p have led us to investigate the role of a particular phosphorylation site on the scaffold protein Ste5p and its potential role in feedback or cross-talk. Lastly, I intend to briefly discuss tools we are developing to study cross-talk between different pathways at single cell level.

Type of Seminar:
IfA BISON Seminar
Dr. Frank van Drogen
ETHZ, Department of Biology, Institute of Biochemistry
May 03, 2011   13:30

Contact Person:

Elias August
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Biographical Sketch: