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The Role of Process Systems Engineering in Physiology and Clinical Medicine

The talk will discuss the role that Chemical Engineers, and in particular Process Systems Engineers, can play in problems in physiology and clinical medicine, in collaboration with life and clinical scientists. What is needed are systems approaches to understanding and modelling complex chemical and physical (particularly molecular transport in complex flow regimes) interactions at multiple scales in living systems through Chemical Engineering analysis. Engineering design techniques will be increasingly needed for biological and medical advances to be able to make reliable system-wide predictions of their effects of the interventions, such as the introduction of chemical and biochemical pharmacological agents, through clinical interventions, or by genetic techniques.
The talk will draw on two recent projects at UCL. The first is a project which is building an in-silico model of the human liver, scaling up models from the molecular level to the liver, an epithelial organ. The composite model so far models glucose regulation in the liver and associated organs. The second project has modeled the effects of blood flow on endothelial cells lining arteries, taking into account cell shape change resulting in changes in the cell skeleton which cause consequent chemical changes. Both projects involve molecular transport, chemical reactions, and complex multiscale systems, all attributes of systems with which Process Systems Engineers have experience.

Type of Seminar:
IfA Seminar
Prof. David Bogle
Graduate School, University College London
Oct 06, 2011   11:15

ETZ E 8, Gloriastrasse 35
Contact Person:

John Lygeros
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Biographical Sketch:
David Bogle is Professor of Chemical Engineering and Head of the Graduate School at University College London. He undertakes research and teaching in process design and process control for both chemical and biochemical processes and in Systems Biology. He is a Chartered Engineer, a Fellow the Royal Academy of Engineering and of the Institution of Chemical Engineers. He represents the U.K. on the Working Party on Computer Aided Process Engineering of the European Federation of Chemical Engineering, and on the Technical Committees on Chemical Process Control and on Modeling and Control of Environmental Systems of the International Federation of Automatic Control, and is a member of Natural Science Committee of UK Delegation to UNESCO. He is a member of the College of Engineering of the UK's Engineering and Physical Sciences Research Council, and was on the Integrated and Systems Biology and the Bioscience Skills and Careers Strategy Boards of the Biotechnology and Biological Sciences Research Council from 2006 until 2010. For 2006 he was also Director of the Centre for Process Systems Engineering, a joint Centre between Imperial College and UCL and is currently Deputy Director.
David Bogle studied Chemical Engineering at Imperial College at both undergraduate and graduate levels, receiving his PhD in 1983. Following this, he worked on modelling and control projects for British Gas before taking a position as lecturer at the University of Adelaide, a position he held from 1986 until 1990. David Bogle joined UCL as a lecturer in 1990. In 2005 he was appointed Head of the UCL Graduate School. He was elected a Fellow of the Royal Academy of Engineering in 2005.