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Towards multi-level models of systemic inflammation: A translational systems biology approach

The inflammatory response initiates the healing and recovery from injury. When successful, it leads to the restoration of homeostasis; otherwise elevated levels of inflammatory activity may exert deleterious effects. Given the inherent complexity of the inflammatory response, the development of novel therapies aiming at its modulation has been slow. In this talk, we discuss our work on human endotoxemia, as model of systemic inflammation, demonstrating how translational systems biology approaches can enable the rationalization and control of the response. A critical component of our work focuses on the role of physiologic variability and rhythmic biological signals in restoring and maintaining homeostasis.

Type of Seminar:
IfA Seminar
Prof. Ioannis Androulakis
Biomedical and Chemical & Biochemical Eng., Rutgers University , New Jersey
May 23, 2013   5:15 pm

Contact Person:

Prof. John Lygeros
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Biographical Sketch:
Dr. Androulakis received his B.S. in Chemical Engineering from the National Technical University of Athens, Greece, and he subsequently obtained his M.S and Ph.D. from Purdue University, USA. He spent two years at Princeton University as a research associate before joining ExxonMobil's Corporate Strategic Research Laboratories, where he eventually became the Informatics and Knowledge Capitalization technical project leader before joining Rutgers University where he holds appointments with the Departments of Biomedical Engineering and Chemical & Biochemical Engineering and the Surgery Department at the Robert Wood Johnson Medical School. His work is currently funded by the US Environmental Protection Agency, the National Science Foundation, the Office of Naval Research, and the National Institutes of Health. His work focuses on systems biology of inflammation and the interplay between biological rhythms and immune response.