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Challenges and Opportunities in Addressing Problems of High Complexity in Process Industry

In this talk I will be discussing a couple of problems currently considered in my lab. The first one comes from the pharmaceutical industry and the second one is a problem that cuts across different industrial sectors and has been an active research area for the last few decades. The $600 billion/year pharmaceutical industry is an important sector in which the U.S. remains a global leader. Regulatory authorities have recognized the deficiencies of pharmaceutical product manufacturing and aim to enhance process understanding through Quality by Design (QbD) and Process Analytical Technology (PAT) tools. As a result of this current effort to change the mindset in order to mimic the rest of the chemical industry, an additional transition is becoming more and more appealing: transition from batch to continuous mode. However, continuous manufacturing requires detailed process understanding in terms of the evolution of all critical material properties as a function of its operating parameters and environmental conditions. Once process knowledge is translated into models, computer aided dynamic simulation tools will allow the design, analysis and optimization of continuous integrated processes. Modeling and optimization tools towards this direction will be discussed. The second problem is common among different process industries that face major new challenges through increased global competition, greater regulatory pressures and uncertain prices of energy, raw materials and products. These competitive concerns increase the focus on integrated processes, information technology, and consideration of multiple design criteria including profitability, flexibility, quality, and the environment. The success of any industrial sector will depend on how efficiently it generates value by dynamically optimizing deployment of its supply chain resources. Ideas and approaches towards integrating planning, scheduling and dynamic optimization as well as moving towards supply chain management with high level of granularity at the lower levels will be presented. The consideration of uncertainty is also of importance at this problem and will be discussed.

Type of Seminar:
IfA Seminar
Prof. Marianthi Ierapetritou
Department of Chemical and Biochemical Engineering at Rutgers State University of New Jersey, USA
Mar 07, 2013   4:15 p.m.

ETZ E8, Gloriastrasse 35
Contact Person:

John Lygeros
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Biographical Sketch:
Marianthi Ierapetritou is a Professor in the Department of Chemical and Biochemical Engineering at Rutgers University in Piscataway, New Jersey. She obtained her BS from National Technical University in Athens, Greece, her PhD from Imperial College (London, UK) in 1995 and subsequently completed post-doctoral research at Princeton University (Princeton, NJ) before joining Rutgers University in 1998. Among her accomplishments is the Outstanding Faculty Award in 2012, the Rutgers Board of Trustees Research Fellowship for Scholarly Excellence in 2004, and the prestigious NSF CAREER award in 2000. Marianthi research focuses on the following areas: 1) Process operations; (2) design and synthesis of flexible manufacturing systems; 3) modeling of reactive flow processes; and 4) metabolic engineering. She has published 152 papers and presented in national and international conferences (147 presentations). She was invited to present her work in a number of universities and conferences around the world (47 invitations). She is also a member of AIChE, INFORMS and SIAM and an active participant in the scientific advising committees of ESCAPE 16, 17, 21, 22, 23, PSE 2006, 2009, 2012, FOCAPD 2009, and FOCAPO 2012. In 2008 she was the organizer of the fifth international FOCAPO conference. She is an active educator both in the classroom teaching graduate and undergraduate classes in the Chemical Engineering department and as an advisor currently supervising the Ph.D. of 7 students and 1 postdoctoral fellow. Her research work is supported by federal (NSF, ONR, PRF, EPA, NIH) and industrial support (Pfizer, ExxonMobil, BOC). Marianthi has been active in CAST division of the AIChE as a program director for the last two years and she was elected last year as a vice chair. In her role as a second vice-chair last year, she initiated an enhancement of the Student travel award to include the Student presentation award, which was implemented with great success. She has also been a chair for the area 10A programming in 2006 and an elected Trustee of CACHE for the last 7 years where last year was elected as vice president.