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Automatic Control of Simulated Moving Beds-Nonlinear Isotherm


G. Erdem

International Symposium, Exhibit & Workshops on Preparative//Process Chromatography, Baltimore, MD, USA, Ion exchange, Adsorption/Desorption Processes & Related Separation Techniques

Simulated moving bed (SMB) chromatography has become a widely used technology in the areas of pharmaceutical and fine chemicals in which complex separation tasks are faced on daily bases. Nevertheless, operation of SMB units at their optimal operating conditions is still an open issue due to absence of proper feedback control schemes. We have developed a feedback control scheme that integrates on-line optimization and control of SMB units. A significant feature of the developed SMB control concept is that it requires only the overall average packing characteristic of the SMB unit and the knowledge of the linear adsorption isotherm regardless of the type of isotherm characterizing the mixture to be separated. Therefore it removes the necessity of detailed characterization of the columns and the separation system under consideration. We will provide the first experimental results to verify the developed on-line optimization based control concept.


Type of Publication:


M. Morari

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