Note: This content is accessible to all versions of every browser. However, this browser does not seem to support current Web standards, preventing the display of our site's design details.


Annihilation of Single Cell Neural Oscillations by Feedforward and Feedback Control


F. Fröhlich, S. Jezernik

Journal of Computational Neuroscience, vol. 17, no. 2, pp. 165-178, Journal of Computational Neuroscience, Vol.17(2), pp.165-178, Sept./Oct. 2004

Annihilation of neural oscillation by localized electrical stimulation has been shown to be a promising treatment modality in a number of neural diseases like Parkinson disease or epilepsy. The contributions presented in this manuscript comprise newly developed stimulation schemes to achieve annihilation of action potential generation and action potential propagation. The ability to achieve oscillation annihilation is demonstrated in computer simulations with a single compartment nerve cell model (annihilation of action potential generation), and with a multi-compartment nerve fiber model (annihi- lation of action potential propagation). Additionally, we show superiority of the new feedback based schemes over the feedforward schemes in terms of effectiveness, phase ro- bustness, and reduced sensitivity to disturbances. At the end we propose a conditioned switched feedback control regime to be applied in actual applications, where oscillation annihilation is needed.


Type of Publication:


No Files for download available.
% Autogenerated BibTeX entry
@Article { Fr_Jez:2004:IFA_1906,
    author={F. Fr{\"o}hlich and S. Jezernik},
    title={{Annihilation of Single Cell Neural Oscillations by
	  Feedforward and Feedback Control}},
    journal={Journal of Computational Neuroscience},
Permanent link