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Feedback Control of Hodgkin-Huxley Nerve Cell Dynamics


F. Fröhlich, S. Jezernik

IFAC Symposium on Modelling and Control in Biomedical Systems, Melbourne, Australia, pp. 439-443

Two feedback schemes for controlling nerve cell dynamics governed by the Hodgkin-Huxley model were designed and evaluated in computer simulations. By combining a state feedback controller for control of the membrane voltage with an optimal controller (model predictive control, MPC), a closed-loop cascaded control of the essential biophysical states causing electrical signal generation in nerve cells was achieved. These states correspond to ion channel opening and closing. The controller permitted control of nerve cell dynamics in presence of disturbances. The use of MPC allowed the generation of biophysically plausible control signals by tuning both the cost function and the constraints on the controller output. These new theoretical developments can open new possibilities in the design of electrical stimulation rehabilitation systems.


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% Autogenerated BibTeX entry
@InProceedings { Fr_Jez:2003:IFA_195,
    author={F. Fr{\"o}hlich and S. Jezernik},
    title={{Feedback Control of Hodgkin-Huxley Nerve Cell Dynamics}},
    booktitle={IFAC Symposium on Modelling and Control in Biomedical
    address={Melbourne, Australia},
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