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Optimal operation of simulated moving bed units by optimizing feedback control


G. Erdem, M. Amanullah, S. Abel, M. Morari, M. Mazzotti, M. Morbidelli

The seventh Italian Conference on Chemical and Process Engineering, Giardini Naxos, Italy

The simulated moving bed (SMB) chromatography has become a powerful alternative for the complex separation tasks that are regularly encountered in the areas of pharmaceuticals, fine chemicals and biotechnology (Imamoglu, 2002). On the other hand, robust operation of SMB units at their economic optimum is still an open issue because of the high sensitivity of the process performance to disturbances and uncertainties in the system. We have recently developed an on-line optimization based control scheme that can deliver the economic optimum of the SMB process despite the above difficulties (Erdem et al., 2004a; Abel et al., 2004a). This paper reports the experimental verification of the control concept on a lab-scale SMB unit used for the high purity separation of nucleosides (uridine and guanosine).


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M. Morari

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% Autogenerated BibTeX entry
@InProceedings { ErdEtal:2005:IFA_2103,
    author={G. Erdem and M. Amanullah and S. Abel and M. Morari and M. Mazzotti and M.
    title={{Optimal operation of simulated moving bed units by
	  optimizing feedback control}},
    booktitle={The seventh Italian Conference on Chemical and Process
    address={Giardini Naxos, Italy},
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