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Pharmacodynamic modelling of drug-induced ventilatory depression and automatic drug dosing in conscious sedation


E. Zanderigo, A. Caruso, T. Bouillon, M. Luginbühl, M. Morari

Conf Proc IEEE Eng Med Biol Soc 2006, pp. 5029-32; New York, NY

In conscious sedation (CS) procedures, the patient is sedated but retains the ability to breathe spontaneously. Drug-induced ventilatory depression represents a dangerous side effect of CS, possibly leading to hypoventilation and subsequent hypoxia. In this work, we propose a new pharmacodynamic model for drug-induced ventilatory depression. The model presents a parsimonious structure and shows good agreement with experimental data for different drugs. In addition, we explore the innovative idea of regulating drug infusion during CS by means of a feedback control system based on measurements of transcutaneous partial pressure of CO2. In simulations, the controller proves able to maintain a predefined target of CO2 despite pain, external disturbances and inter-patient variability in the sensibility to the drug. The implementation of the controller during CS procedures would improve clinical practice minimizing the occurrence of drug-induced ventilatory depression by tailoring drug infusion to patient’s needs.


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M. Morari

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% Autogenerated BibTeX entry
@Article { ZanEtal:2006:IFA_2464,
    author={E. Zanderigo and A. Caruso and T. Bouillon and M. Luginb{\"u}hl and M.
    title={{Pharmacodynamic modelling of drug-induced ventilatory
	  depression and automatic drug dosing in conscious sedation}},
    journal={Conf Proc IEEE Eng Med Biol Soc 2006},
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