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A parsimonious model integrating drug effect on the hypercarbic and hypoxic ventilatory drive


A. Caruso

ASA - American Society of Anesthesiologists Annual Meeting, San Francisco, CA

Multiple studies are available describing i) the effect of oxygen on the hypercarbic respiratory drive (HCRD), ii) the effect of carbon dioxide on the acute hypoxic respiratory drive (AHORD), iii) the effect of drugs on the HCRD and iv) the effect of drugs on the AHORD. Unfortunately, most of them are not suitable for simulation, inter/extrapolation and dose finding. This is due to the experimental paradigms geared towards isolating physiologic phenomena in order to obtain reliable and interpretable data of respiratory subsystems. We propose to integrate the available knowledge with a parsimonious interaction model.


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M. Morari

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