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TCI for multiple drugs: the two dimensional user interface approach

Author(s):

A. Caruso		 Conference/Journal:

First World Congress of Total Intravenous Anaesthesia - TIVA TCI, Venice, Italy
Abstract:

No integrated platform has emerged that supports TCI dosing of several drugs. Separate TCI pumps for propofol and remifentanil or alfentanil cannot account for the 15%-reduced remifentanil/alfentanil elimination caused by propofol. These requirements were defined for a combined TCI system: 1) interacting pharmacokinetics are considered for model calculation of TCI dosing profiles, 2) drug dosing can be changed for all pumps through a single point of interaction, 3) dosing is based on a relevant endpoint for anesthesia (effect steering), 4) changing the hypnotic/opioid concentration ratio shall not unintentionally change depth of anesthesia. A prototype was built using MATLAB to verify results in simulations.

Year:

2007
Type of Publication:

(06)Talk
Supervisor:

M. Morari

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