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DNA replication modeling and analysis


K. Koutroumpas

IfA Internal Seminar Series

DNA replication is the process of duplication of cellsí genetic material, which is very important for the life of the cell. In order to start replication, DNA helix must be opened and unwound in specific regions along the genome, called origins of replication. In the sequel, replication continues outward in both directions from the origin. The process stops when there are exactly two copies of the initial strand (one for each daughter cell). To ensure that each region of the genome is replicated once and only once, originsí action is supervised by the cell-cycle control system. However, there are some cases that the control system fails resulting in incomplete replication or rereplication of parts of the chromosome. In this presentation, a short description of the DNA replication model some interesting parameter identification results will be shown followed by the description an extended model that captures the DNA rereplication dynamics. The presentation will be concluded with a method that can be used to extract origin characteristics and to predict their location.


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