Note: This content is accessible to all versions of every browser. However, this browser does not seem to support current Web standards, preventing the display of our site's design details.

  

Implementation of an automated on-line high-performance liquid chromatography monitoring system for ‘cycle to cycle’ control of simulated moving beds

Author(s):

C. Langel, C. Grossmann, M. Morbidelli, M. Morari, M. Mazzotti
Conference/Journal:

Journal of Chromatography A, vol. 1216, no. 50, pp. 8806-8815
Abstract:

In continuous chromatography simulated moving bed (SMB) is a firmly established powerful technique for the separation of fine chemicals and enantiomers. The use of a controller could improve the operation conditions and increase the productivity of an SMB unit. However, the performance of any controller is greatly affected by the reliability and the quality of the feedback information from the plant. Therefore, to overcome the limitations of optical detectors, such as UV and polarimeter, an automated on-line HPLC monitoring system was developed and installed to monitor the product streams. The performance of the system is tested experimentally separating a mixture of guaifenesin enantiomers on Chiralcel OD columns with ethanol as mobile phase in our laboratory SMB unit under both linear and nonlinear chromatographic conditions. The results show that the new monitoring system provides precise and accurate data about the concentration of the components in the two product streams. Moreover, they prove that despite disturbances a combination of the controller and the new on-line monitoring system allows to fulfill the product specifications and to improve the performance of the process in terms of feed throughput and solvent consumption.

Year:

2009
Type of Publication:

(01)Article
Supervisor:



No Files for download available.
% Autogenerated BibTeX entry
@Article { LanEtal:2009:IFA_3268,
    author={C. Langel and C. Grossmann and M. Morbidelli and M. Morari and M.
	  Mazzotti},
    title={{Implementation of an automated on-line high-performance
	  liquid chromatography monitoring system for ‘cycle to
	  cycle’ control of simulated moving beds}},
    journal={Journal of Chromatography A},
    year={2009},
    volume={1216},
    number={50},
    pages={8806--8815},
    month=dec,
    url={http://control.ee.ethz.ch/index.cgi?page=publications;action=details;id=3268}
}
Permanent link