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Combination of Polymer Technology and Carbon Nanotube Array for the Development of an Effective Drug Delivery System at Cellular Level

Author(s):

S. Micera, G. Ciofani, A. Cuschieri, V. Raffa, C. Riggio
Conference/Journal:

Nanoscale Research Letters, vol. tba,
DOI 10.1007/s11671-009-9291-0
Abstract:

In this article, a carbon nanotube (CNT) arraybased system combined with a polymer thin film is proposed as an effective drug release device directly at cellular level. The polymeric film embedded in the CNT array is described and characterized in terms of release kinetics, while in vitro assays on PC12 cell line have been performed in order to assess the efficiency and functionality of the entrapped agent (neural growth factor, NGF). PC12 cell differentiation, following incubation on the CNT array embedding the alginate delivery film, demonstrated the effectiveness of the proposed solution. The achieved results indicate that polymeric technology could be efficiently embedded in CNT array acting as drug delivery system at cellular level. The implication of this study opens several perspectives in particular in the field of neurointerfaces, combining several functions into a single platform.

Keywords Vertically aligned carbon nanotubes  Drug delivery  Alginate  NGF  PC12 cells

Year:

2009
Type of Publication:

(01)Article
Supervisor:



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% Autogenerated BibTeX entry
@Article { MicEtal:2009:IFA_3329,
    author={S. Micera and G. Ciofani and A. Cuschieri and V. Raffa and C. Riggio},
    title={{Combination of Polymer Technology and Carbon Nanotube Array
	  for the Development of an Effective Drug Delivery System at
	  Cellular Level}},
    journal={Nanoscale Research Letters},
    year={2009},
    volume={tba},
    number={},
    pages={},
    url={http://control.ee.ethz.ch/index.cgi?page=publications;action=details;id=3329}
}
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