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Model predictive control for propofol sedation

Author(s):

A. Caruso
Conference/Journal:

World Congress on Medical Physics and Biomedical Engineering, Munich, Germany
Abstract:

This work discusses the application of Model Predictive Control (MPC) to administer propofol for the delivery of sedation. Control of drug infusion is based on the transcutaneous partial pressure of carbon dioxide (PtcCO2), a readily available, noninvasive measure of the most significant pharmacologic side effect, and the effect site concentration of the drug (Ce). A side effect is considered because of the lack of a reliable measure of sedation. The performance of the controller is tested by requesting stepwise adjustments in PtcCO2 from baseline to mild and severe hypercarbic levels [45-60 mmHg] for several virtual patients with significant variability in drug sensitivity. The simulation results are encouraging towards the applicability of the proposed dosing paradigm in the anesthetic practice. A proof-of-concept study is currently being performed.

Year:

2009
Type of Publication:

(06)Talk
Supervisor:

M. Morari

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