Note: This content is accessible to all versions of every browser. However, this browser does not seem to support current Web standards, preventing the display of our site's design details.


Model predictive control for propofol sedation


A. Caruso

World Congress on Medical Physics and Biomedical Engineering, Munich, Germany

This work discusses the application of Model Predictive Control (MPC) to administer propofol for the delivery of sedation. Control of drug infusion is based on the transcutaneous partial pressure of carbon dioxide (PtcCO2), a readily available, noninvasive measure of the most significant pharmacologic side effect, and the effect site concentration of the drug (Ce). A side effect is considered because of the lack of a reliable measure of sedation. The performance of the controller is tested by requesting stepwise adjustments in PtcCO2 from baseline to mild and severe hypercarbic levels [45-60 mmHg] for several virtual patients with significant variability in drug sensitivity. The simulation results are encouraging towards the applicability of the proposed dosing paradigm in the anesthetic practice. A proof-of-concept study is currently being performed.


Type of Publication:


M. Morari

File Download:

Request a copy of this publication.
(Uses JavaScript)
% No recipe for automatically generating a BibTex entry for (06)Talk
Permanent link