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Invalidation of the structure of genetic network dynamics: A geometric approach

Author(s):

R. Porreca, E. Cinquemani, J. Lygeros, G. Ferrari-Trecate
Conference/Journal:

vol. AUT11-11
Abstract:

This work concerns the identification of the structure of a genetic network model from measurements of gene product concentrations and synthesis rates. In earlier work, we developed a data preprocessing algorithm that is able to reject many hypotheses on the network structure by testing certain monotonicity properties for a wide family of network models. Here we develop a geometric interpretation of the method. Then, for a relevant subclass of genetic network models, we extend our approach to the combined testing of monotonicity and convexity-like properties associated with the network structures. The theoretical aspects and practical performance of the enhanced methods are illustrated by way of numerical results.

Year:

2011
Type of Publication:

(04)Technical Report
Supervisor:



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% Autogenerated BibTeX entry
@TechReport { PorEtal:2011:IFA_3804,
    author={R. Porreca and E. Cinquemani and J. Lygeros and G. Ferrari-Trecate},
    title={{Invalidation of the structure of genetic network dynamics:
	  A geometric approach}},
    institution={},
    year={2011},
    number={},
    address={},
    url={http://control.ee.ethz.ch/index.cgi?page=publications;action=details;id=3804}
}
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