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Finding Physiological Responses in Vestibular Evoked Potentials

Author(s):

K. Nguyen, Vinzenz Kögler, J. DiGiovanna, S. Micera
Conference/Journal:

IEEE Engineering in Medicine and Biology Conference, Boston, MA, USA
Abstract:

Vestibular prostheses are regarded as a promising tool to restore lost sensation in patients with vestibular disorders. These prostheses often electrically stimulate the vestibular nerve and stimulation efficacy is evaluated by measuring the vestibulo-ocular reflex (VOR). However, eye movement recording as intuitive metric of vestibular functionality is difficult to obtain outside the laboratory environment, and hence not available as an error signal in a closed-loop prosthesis. Recently we investigated vestibular evoked potentials (VEPs) as potential feedback signal by stimulating and recording in the same semicircular canal of a guinea pig. Here we studied the correlation between VOR and one region of VEP. We further analyzed a second portion of VEP, where vestibular nerve activity should occur using rectified bin integration (RBI). To this end, stimulation artifact was significantly reduced by hardware and software approaches. We found a high VEP-VOR correlation (R-squared=0.86), suggesting that VEP could substitute VOR as metric in a closed-loop prosthesis. Differences between below and above vestibular threshold stimulation were seen for the second portion of VEP. However, further investigations are required to determine the specific part of VEP that would be optimal for feedback control.

Year:

2011
Type of Publication:

(01)Article
Supervisor:

S. Micera

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% Autogenerated BibTeX entry
@InProceedings { NguEtal:2011:IFA_3813,
    author={K. Nguyen and Vinzenz K{\"o}gler and J. DiGiovanna and S. Micera},
    title={{Finding Physiological Responses in Vestibular Evoked
	  Potentials}},
    booktitle={IEEE Engineering in Medicine and Biology Conference},
    pages={},
    year={2011},
    address={Boston, MA, USA},
    month=aug,
    url={http://control.ee.ethz.ch/index.cgi?page=publications;action=details;id=3813}
}
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