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Comparing Artifact Reduction Methods for Recording Vestibular Evoked Potentials in a Vestibular Neuroprosthesis

Author(s):

K. Nguyen, J. DiGiovanna, S. Micera
Conference/Journal:

Engineering in Medicine and Biology Society Conference, San Diego, Accepted as late breaking research and will be presented as poster
Abstract:

The vestibular organs in the inner ear detect linear acceleration and rotation of the head. This sensory input is critical in activities of daily life and patients with bilateral vestibular loss can experience severe deficits in gaze stability, spatial orientation and postural control. Several research groups are working on vestibular implants to address vestibular disorders. The CLONS project is developing a closed-loop vestibular prosthesis and is investigating vestibular evoked potentials (VEP) as feedback signal. One prerequisite to using VEP is effective stimulation artifact reduction. In cochlear implants, the masker probe (MP) method rejects artifact to measure compound action potentials. However, this method is inapt for a closed-loop vestibular prosthe¬sis due to limited recording time (stimulation frequencies up to 400 Hz) and the undesirable physiological response (activating all proximal neurons) to the masker pulse. Here, we investigated an approach that learns a probe artifact template (PAT) from masker probe recordings and compare it to the MP method and a sub-threshold template. Experiments were performed in one, male guinea pig instrumented with a multi-site electrode array. Different sites were used for stimulating and recording, and all experiments were approved by the institutional animal care and use com-mittee. The PAT method proved to be a qualified proxy for the MP method, whereas template subtraction was distorted. The growth functions of the MP and PAT methods were also similar. In future, the growth functions can be used to establish a correlation to eye movement responses. This correlation will be an essential building block of the closed-loop vestibular prosthesis.

Year:

2012
Type of Publication:

(15)Miscellaneous
Supervisor:

S. Micera

No Files for download available.
% Autogenerated BibTeX entry
@Misc { NguDiG:2012:IFA_4164,
    author={K. Nguyen and J. DiGiovanna and S. Micera},
    title={{Comparing Artifact Reduction Methods for Recording
	  Vestibular Evoked Potentials in a Vestibular
	  Neuroprosthesis}},
    month=aug,
    year={2012},
    url={http://control.ee.ethz.ch/index.cgi?page=publications;action=details;id=4164}
}
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