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Spatial and Dynamical Properties of Yeast Signaling


Maike Roth

Research Project, HS12 (10203)

Signaling in yeast enables the cell to respond to changes in the environment. Ad- ditionally it is important in generating a polarisation pole for mating and budding. This requires a tight controlled spatial polarization of the cell towards a target direction. Clusters of signaling molecules in the membrane encode this direction information Here we investigated properties of such cluster formation in a simpli ed model based on CDC42 interactions. We simulated the spatial dynamics with a novel particle based simulation tool and evaluated the spatial properties of the resulting particle distributions. Thus we were able to locate parameter regions that enable clustering. Furthermore we outline how the CDC42 polarization marker can be included in a wholistic spatial signaling model.


Type of Publication:

(13)Semester/Bachelor Thesis

M. Klann

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% Autogenerated BibTeX entry
@PhdThesis { Xxx:2012:IFA_4285
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