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Growth rate estimation of β L-glutamic acid from online measurements of multidimensional particle size distributions and concentration


D. Ochsenbein, S. Schorsch, T. Vetter, M. Mazzotti, M. Morari

Industrial & Engineering Chemistry Research, vol. 53, no. 22, pp. 91369148

A protocol for the estimation of growth kinetics for complex-shaped particles is presented. The estimation is based on multidimensional particle size distribution (nD PSD) and concentration data. While the latter is obtained by an in situ midinfrared absorption probe, nD PSD data is measured via an imaging based setup presented earlier. The data is fitted to the output of a morphological population balance equation, which is solved by a customized high resolution algorithm. The procedure is first validated in silico using a virtual implementation of the measurement setup before it is applied to seeded desupersaturation experiments of the β polymorph of L-glutamic acid. Prominent broadening of the product PSD is observed and different size (in)dependent growth models are fitted to the data. Confidence intervals, local identifiability, and correlation of the parameters are studied. Finally, the estimated growth rate is compared to literature results.


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% Autogenerated BibTeX entry
@Article { OchEtal:2014:IFA_4575,
    author={D. Ochsenbein and S. Schorsch and T. Vetter and M. Mazzotti and M.
    title={{Growth rate estimation of \β L-glutamic acid from
	  online measurements of multidimensional particle size
	  distributions and concentration}},
    journal={Industrial \& Engineering Chemistry Research},
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