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A Real-Time Research Platform to Study Vestibular Implants with Gyroscopic Inputs in Vestibular Deficient Subjects


K. Nguyen, Maurizio Ranieri, J. DiGiovanna, Otto Peter, Vincenzo Genovese, Angelica Perez-Fornos, S. Micera

IEEE Transactions on Biomedical Circuits and Systems, vol. 8, no. 4, pp. 474-484

Researchers have succeeded in partly restoring damaged vestibular functionality in several animal models. Recently, acute interventions have also been demonstrated in human patients. Our previous work on a vestibular implant for humans used predefined stimulation patterns; here we present a research tool that facilitates motion-modulated stimulation. This requires a system that can process gyroscope measurements and send stimulation parameters to a hybrid vestibular-cochlear implant in real-time. To match natural vestibular latencies, the time from sensor input to stimulation output should not exceed 6.5 ms. We describe a system based on National Instrumentís Com-pactRIO platform that can meet this requirement and also offers floating point precision for advanced transfer functions. It is designed for acute clinical interventions, and is sufficiently powerful and flexible to serve as a development platform for evaluating prosthetic control strategies. Amplitude and pulse frequency modulation to predetermined functions or sensor inputs have been validated. The system has been connected to human patients, who have received a modified MED-EL cochlear implants for vestibular stimulation.


Type of Publication:


S. Micera

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author={Nguyen, T.A.K. and Ranieri, M. and DiGiovanna, J. and Peter, O. and Genovese, V. and Perez Fornos, A. and Micera, S.}, 
journal={Biomedical Circuits and Systems, IEEE Transactions on}, 
title={A Real-Time Research Platform to Study Vestibular Implants With Gyroscopic Inputs in Vestibular Deficient Subjects}, 
keywords={biological organs;biomedical measurement;cochlear implants;design;gyroscopes;mechanoception;medical control systems;medical disorders;medical signal processing;pattern matching;pulse amplitude modulation;pulse frequency modulation;real-time systems;transfer functions;National Instrument CompactRIO platform;acute clinical interventions;advanced transfer functions;amplitude modulation;animal models;damaged vestibular functionality restoration;design;floating point precision;function predetermination;gyroscope measurement processing;gyroscopic inputs;human patient vestibular implant;hybrid vestibular-cochlear implant;modified MED-EL cochlear implant;motion-modulated stimulation;natural vestibular latency matching;patient tests;predefined stimulation patterns;prosthetic control strategy evaluation;pulse frequency modulation;real-time research platform;real-time stimulation parameter transfer;sensor input time;sensor inputs;stimulation output time;vestibular deficient subjects;vestibular implants;vestibular stimulation;Angular velocity;Cochlear implants;Electrodes;Field programmable gate arrays;Frequency modulation;CompactRIO;real-time processing;vestibular implant}, 
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