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DNA Replication


Z. Lygerou, K. Koutroumpas, J. Lygeros

pp. 610-614, Encyclopedia of Systems Biology (K.C.W. Dubitzky, O. Wolkenhauer, H. Yokota, eds.)

DNA replication is the process of making an identical copy of the genetic material within each cell (Alberts et al. 2007; DePamphilis 2006). In eukaryotes, DNA replication takes place during a defined period of the cell cycle, called S (for synthesis) phase. DNA replication must be carried out with great precision every time the cell divides, so that genetic information is preserved. Control mechanisms ensure that every base of the genome is replicated once and only once per cell cycle, thereby safeguarding genomic integrity.


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