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The vestibular implant: Frequency-dependency of the electrically evoked Vestibulo-Ocular Reflex in humans

Author(s):

Raymond van de Berg, Nils Guinand, K. Nguyen, Maurizio Ranieri, Samuel Cavuscens, Jean-Philippe Guyot, Robert Stokroos, Herman Kingma, Angelica Perez-Fornos
Conference/Journal:

Frontiers in Systems Neuroscience, vol. 8, no. 255, pp. NA, Accepted, in press: 29 Dec 2014
Abstract:

A strong and significant effect of frequency was observed in the total peak eye velocity of the eVOR. This effect was similar to that observed in the “natural” VOR. Other characteristics of the (e)VOR (angle, habituation-index, and asymmetry) showed no significant frequency-dependent effect. In conclusion, this study demonstrates that, at least at the specific (limited) frequency range tested, responses elicited by a vestibular implant closely mimic the frequency-dependency of the “normal” vestibular system.

Year:

2014
Type of Publication:

(01)Article
Supervisor:



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@ARTICLE{10.3389/fnsys.2014.00255,
  
 AUTHOR={Van De Berg, Raymond  and  Guinand, Nils  and  Nguyen, Khoa  and  Ranieri, Maurizio  and  Cavuscens, Samuel  and  GUYOT, Jean-Philippe  and  Stokroos, Robert  and  Kingma, Herman  and  Perez Fornos, Angelica},   
	 
TITLE={The vestibular implant: Frequency-dependency of the electrically evoked Vestibulo-Ocular Reflex in humans},      
	
JOURNAL={Frontiers in Systems Neuroscience},      
	
VOLUME={8},      
	
YEAR={2014},      
	
NUMBER={255},     
	  
URL={http://www.frontiersin.org/systems_neuroscience/10.3389/fnsys.2014.00255/abstract},       
	
DOI={10.3389/fnsys.2014.00255},      
	
ISSN={1662-5137} ,      
	
ABSTRACT={The Vestibulo-Ocular Reflex (VOR) shows frequency-dependent behavior. This study investigated whether the characteristics of the electrically evoked VOR (eVOR) elicited by a vestibular implant, showed the same frequency-dependency.
Twelve vestibular electrodes implanted in 7 patients with bilateral vestibular hypofunction were tested. Stimuli consisted of amplitude-modulated electrical stimulation with a sinusoidal profile at frequencies of 0.5Hz, 1Hz, and 2Hz. The main characteristics of the eVOR were evaluated and compared to the “natural” VOR characteristics measured in a group of age-matched healthy volunteers who were subjected to horizontal whole body rotations with equivalent sinusoidal velocity profiles at the same frequencies.
A strong and significant effect of frequency was observed in the total peak eye velocity of the eVOR. This effect was similar to that observed in the “natural” VOR. Other characteristics of the (e)VOR (angle, habituation-index, and asymmetry) showed no significant frequency-dependent effect. In conclusion, this study demonstrates that, at least at the specific (limited) frequency range tested, responses elicited by a vestibular implant closely mimic the frequency-dependency of the “normal” vestibular system.}}
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