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Closed loop control in anesthesia


M. Morari

Vancouver, Canada, Exploratory Workshop: Automation and Robotics - The Key to Computer Integrated Health Care Delivery, University of British Columbia

The Automatic Control Laboratory at ETH is developing a multi-task autonomous anesthesia system in collaboration with the University Hospital in Bern. Previously, closed loop controllers which regulate inspired and expired anesthetic Gas, O2 and CO2 concentrations have been used in clinical studies on humans. In this paper two more complex controllers are discussed: control of Mean Arterial Pressure (MAP) and control of hypnosis through Bispectral Index (BIS). Both controllers use Isoflurane as input, a hypnotic drug inducing hypotension. The modelling effort and the control design which accommodates for input and output constraints as well as model uncertainty are discussed for both controllers. Moreover the supervisory functions are outlined, which are necessary for application in the Operating Room (OR). In particular, artifact tolerant control schemes are presented. The experimental setup and the results of the application of automatic control during clinical studies are also discussed, together with some outline for future research.


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