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Multitasked closed-loop control in anesthesia


A. Gentilini, C. Frei, A.H. Glattfelder, M. Morari, T. Schnider, T.J. Sieber, R. Wymann, A.M. Zbinden

IEEE Engineering in Medicine and Biology Magazine, vol. 20, no. 1, pp. 39-53

A current reserach project at the Automatic Control Laboratory is developing a multi-task autonomous anaesthesia system. The system has so far being used in clinical studies on human patients to control inspired and expired anaesthetic gas, $O_{2}$ and $CO_{2}$ concentrations. Blood pressure controllers are also tested to induce and maintain hypotension with the inhaled anaesthetic Isoflurane. Still with Isoflurane, control of depth of anaesthesia assessed through Bispectral Index (BIS) is currently being tested in pilot studies. For all studies special attention is paid to the safety requirements of the Operaring Theatre (OT). This includes supervisory functions and artifact tolerant controllers. The paper describes the approaches taken towards that goal as well as parallel and future research directions.

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% Autogenerated BibTeX entry
@Article { GenEtal:2001:IFA_8,
    author={A. Gentilini and C. Frei and A.H. Glattfelder and M. Morari and T.
	  Schnider and T.J. Sieber and R. Wymann and A.M. Zbinden},
    title={{Multitasked closed-loop control in anesthesia}},
    journal={IEEE Engineering in Medicine and Biology Magazine},
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