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Feedforward and Feedback Suppression of Neural Oscillation

Author(s):

F. Fröhlich, S. Jezernik
Conference/Journal:

Annual Meeting of the Society for Neuroscience, New Orleans, USA, Program No. 171.9. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience
Abstract:

Neurons exhibit bistable behavior where the state of the neuron transitions from a resting to an oscillating state and vice versa. A study by Hahn/Durand showed in simulations that a feedforward application of a short current pulse can cause oscillation annihilation. Annihilation occurs due to the bistability of the system, whenever switching from the limit cycle to the fixed point occurs. We extended the parameter space related to the stimulation pulse and used simulations to determine the effect of different stimulus parameters on neural oscillation. The parameters were: relative pulse onset, duration and amplitude. The resulting phase resetting maps displayed the phase shift as a function of stimulus parameters. They showed either two separate regions (phase advance/delay) or three regions (phase advance/delay regions separated by annihilation region). A qualitative condition for oscillation suppression based on the amount of injected charge was derived. Phase plane analysis allowed to explain phase delay/advance, and oscillation suppression from a geometrical viewpoint. We have then developed a controller based on feedback linearization to prescribe the membrane voltage time-course. The controller automatically injects a current such that the desired membrane voltage is obtained. The controller that was driving the system state to the stable fixed-point achieved oscillation annihilation at any phase and exhibited model mismatch and disturbance robustness. The feedback scheme was operating in an on-off regime and was superior to the feedforward scheme. We also applied the feedback control to a multicompartment model, where oscillation annihilation was also demonstrated (permanent operating regime). Thus we were able to effectively block AP propagation. Oscillation suppression by single cell stimulation could be a promising future treatment modality for patients with Parkinson's disease or epilepsy. |||| Ref:P.Hahn,D.Durand:Bistability Dynamics in Simulation of Neural Activity in High-Extracellular-Potassium Conditions.Journal of Comp Neuroscience,Vol.11:5-18,2001.

Year:

2003
Type of Publication:

(01)Article
Supervisor:



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% Autogenerated BibTeX entry
@InProceedings { Fr_Jez:2003:IFA_992,
    author={F. Fr{\"o}hlich and S. Jezernik},
    title={{Feedforward and Feedback Suppression of Neural Oscillation}},
    booktitle={Annual Meeting of the Society for Neuroscience},
    pages={},
    year={2003},
    address={New Orleans, USA},
    month=nov,
    url={http://control.ee.ethz.ch/index.cgi?page=publications;action=details;id=992}
}
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