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Mechanosensing and the regulation of mechanics during cytokinesis

Cytokinesis, the last step in cell division, is an inherently mechanical process. Cytokinesis occurs through the coordinated action of several biochemically-mediated stresses acting on the cytoskeleton. Ensuring that cytokinesis proceeds with high fidelity requires the interaction of biochemical and mechanical modules, forming a system of feedback loops. This integrated system accounts for the regulation and kinetics of cytokinesis furrowing and demonstrates that cytokinesis is a whole-cell process in which the global and equatorial cortices and cytoplasm are active players in the system. In this talk I will describe a multiscale model describing cytokinesis. The talk will highlight the role played by mechanosensation in ensuring that cytokinesis proceeds with high fidelity.

Type of Seminar:
IfA Seminar
Prof. Pablo Iglesias
Electrical and Computer Engineering, Whiting School of Engineering, John Hopkins University, Baltimore
May 22, 2013   11:15 a.m.

ETZ E8, Gloriastrasse 35
Contact Person:

Mustafa Khammash
No downloadable files available.
Biographical Sketch:
Pablo A. Iglesias was born in Caracas, Venezuela. He received the B.A.Sc. degree in Engineering Science from the University of Toronto in 1987, and the Ph.D. Degree in Control Engineering from Cambridge University in 1991. Since then he has been on the faculty of The Johns Hopkins University, where he is currently the Edward J. Schaefer Professor of Electrical Engineering. He also holds appointments in the Departments of Biomedical Engineering, and Applied Mathematics & Statistics. He has had visiting appointments at Lund University, The Weizmann Institute of Science, the California Institute of Technology and the Max Planck Institute for the Physics of Complex Systems, where he is currently on sabbatical. His current research interests focus on the use of control and dynamical system theory to study biological signal transduction pathways, particularly those involved in regulating directed cell motion and cell division.